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☆ I spent my mid-20s managing my autoimmune disease. Autoimmune patients are underserved, so I started a health company to address the problem.
▼ + stars: | 2024-03-17 | by ( Lakshmi Varanasi | ) www.businessinsider.com time to read: +5 min

When I hit my 20s, my health started to change. I also learned that I had Lyme Disease — maybe from a tick bite at Yosemite — which can trigger autoimmune responses. And since 80% of autoimmune patients are women, it became clear to me that this was a women's health crisis that no one was paying attention to. In 2022, I launched WellTheory, a virtual care platform that offers evidence-based nutrition and lifestyle coaching to mitigate autoimmune symptoms. You don't need to look sick to be sick, so they often fly under the radar at workplaces.

Persons: Ellen Rudolph, — Organizations: Yosemite Locations: Yosemite, New York

☆ Morgan Stanley thinks this little-known autoimmune biotech stock can surge more than 40%
▼ + stars: | 2024-03-04 | by ( Pia Singh | ) www.cnbc.com time to read: +2 min

Newly public biotech Kyverna Therapeutics could be a blockbuster cell therapy developer for autoimmune disease, according to Morgan Stanley. The stock opened at $34.25, above the initial public offering price of $22 per share, and closed Friday at $27.75. Although the data from KYV-101 is limited, Ulz wrote that he's "highly encouraged given promising results across multiple indications, multiple sites, and in challenging patients." The analyst pointed out that cell therapies have "meaningfully improved" the treatment of B-cell cancers and that multiple therapies are currently approved, increasing the therapies' potential to treat autoimmune diseases. Ingenui-T is a next-generation process in preclinical development for manufacturing autologous anti-CD19 CAR T-cell therapy, and uses the same CAR construct as KYV-101, Kyverna said.

Persons: Morgan Stanley, Michael Ulz, Kyverna, Ulz Organizations: Therapeutics, Nasdaq, autoimmunity Locations: KYV, Kyverna

☆ Xist molecule: Why autoimmune diseases strike more women than men
▼ + stars: | 2024-02-09 | by ( Katie Hunt | ) edition.cnn.com time to read: +6 min

“Xist is a very long RNA, 17,000 nucleotides long, or letters, and it associates with approximately almost 100 proteins,” Chang said. Chang wondered whether the clumps of protein molecules that arise when Xist connects with the X chromosome were a trigger for autoimmune disease. The experiments weren’t designed to show whether Xist or the related proteins cause autoimmune disease in the animals. The samples from patients with autoimmune disease produced higher levels of autoantibodies in reaction to proteins associated with Xist, the researchers found. Plus, environmental factors play a big role in autoimmune disease.

Persons: Howard Chang, Chang, ”, it’s, Montserrat Anguera, ” Anguera, wasn’t, ” Chang, “ It’s, “ Organizations: CNN, Stanford University, Cell, Stanford School of Medicine, University of Pennsylvania School of Veterinary Medicine Locations: United States, Montserrat

WASHINGTON (AP) — Women are far more likely than men to get autoimmune diseases, when an out-of-whack immune system attacks their own bodies — and new research may finally explain why. One theory is that the X chromosome might be a culprit. The X chromosome is packed with hundreds of genes, far more than males’ much smaller Y chromosome. Every female cell must switch off one of its X chromosome copies, to avoid getting a toxic double dose of all those genes. “We think that’s really important, for Xist RNA to leak out of the cell to where the immune system gets to see it.

Persons: ”, John Wherry, wasn’t, Howard Chang, Chang, ” Chang, Epstein, Barr, Chang’s, Xist, hadn't, Penn’s, they’re, Stanford’s Chang Organizations: WASHINGTON, Stanford University, University of Pennsylvania, Howard Hughes Medical Institute, Associated Press ’ Health, Science Department, Associated Press Health, Howard Hughes Medical Institute’s Science, Educational Media Group, AP

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